National Center for Complementary and Integrative Health, https://nccih.nih.gov/health/redclover/ataglance.htm?nav=gsa. Gastroenterol 1987;93:225-33. Phytochemistry 2003;63(2):209-215. J Nutr 2000;130:656S-7S. Keinan-Boker L, van Der Schouw YT, Grobbee DE, Peters PH. Menopause 2009;16:1167-77. Clin Chim.Acta 2001;312(1-2):213-219. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Tamoxifen (Nolvadex) interacts with RED CLOVER. Use of a mammalian cell culture benzo(a)pyrene metabolism assay for the detection of potential anticarcinogens from natural products: inhibition of metabolism by biochanin A, an isoflavone from Trifolium pratense L. Cancer Res 1988;48:6257-61. Phytoestrogens and cardiovascular health. Some research shows that taking red clover might improve vaginal dryness. Shulman, L. P., Banuvar, S., Fong, H. H., and Farnsworth, N. R. Discussion of a well-designed clinical trial which did not demonstrate effectiveness: UIC center for botanical dietary supplements research study of black cohosh and red clover. This and many more benefits render it quite useful for human ailments. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RED CLOVER. J Agric Food Chem 2004;52:6623-32. The effects of isoflavones derived from red clover on vasomotor symptoms and endometrial thickness. View abstract. 1999;10(8):607-615. Before taking red clover, talk to your healthcare provider if you take any medications that are changed by the liver. Gynecol.Endocrinol. Red Clover Side Effects & Precautions Reported Side Effects. Red clover tea is an excellent natural diuretic to add to your diet. Howes JB, Bray K, Lorenz L, et al. Some medications are changed and broken down by the liver. Nevertheless, you should be aware of its side effects, drug interactions, and risks for certain populations. Gynecol Endocrinol 2008;24(11):620-624. Side effects of bismuth subsalicylate include: estrogen -like effects (bloating, breast tenderness, irregular menstrual periods, decreased sex drive, weight gain, mood changes) View abstract. Red clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. View abstract. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. This is only a brief summary of general information. Beyond ERalpha and ERbeta: Estrogen receptor binding is only part of the isoflavone story. Red clover may cause minor side effects in some women, such as: Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) study: a randomized controlled trial. 2008;26(2):113-173. Find patient medical information for Red Clover Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Phytoestrogens in red clover may accelerate the spread of breast and uterine cancer cells that have estrogen receptors, as well as increase the risk of blood clots and strokes. Mokhtari M, Yousefi M, Bazaz MM, Rakhshandeh H, Vahid H, Ariamanesh AS. It is not life-threatening and many times horses do not show any other symptoms other than excessive salivation. J Nutr 2007;137(2):379-383. Other side effects include wheezing or difficulty breathing. J Nutr 1989;119:1832-8. Cassady JM, Zennie TM, Chae YH, et al. Weak and brittle bones (osteoporosis). JAMA 2003;290:207-14.. View abstract. Menopause Int. Modest hormonal effects of soy isoflavones in postmenopausal women. View abstract. Changes in menstrual periods like lots of bleeding, spotting, or bleeding between cycles. Mol Cell Endocrinol 2007;267(1-2):55-62. J Clin Endocrinol Metab 1999;84:4017-24. Uncontrolled Blood Sugar: How Dangerous Is It? A 2004 study in Menopause demonstrated that this herb is actually contraindicated in people with estrogen-sensitive conditions. Umland EM, Cauffield JS, Kirk JK, et al. Setchell KD. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Title 21. No serious side effects have been reported in studies that evaluated red clover for various health conditions for up to a year. Red clover contains substances called isoflavones. Girls with breast cancer and people that are currently on anticoagulants should consult their doctor before taking this herb. J Clin Endocrinol Metab 1999;84:895-8. View abstract. Red clover poisoning is also known as Slaframine poisoning or the slobbers. Take extra care if you are taking drugs to help with swelling or inflammation. Aging Male 2010;13(2):75-81. There are a few brand name products of RCE (Promensil, Menoflavon, etc.) Menopause 2009;16:1156-66. View abstract. Vincent A, Fitzpatrick LA. Take extra care and check with your doctor if you have: Signs of a very bad reaction. View abstract. 7 Three cups (750 ml) can be drunk each day. Manganese and chronic hepatic encephalopathy. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Treats Infertility. Doses of red clover are standardized from 40 mg to 80 mg of isoflavones (the active ingredient in red clover) per 24 hours is often recommended. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. View abstract. Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others. 2015;36:301-311. Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women. You must talk with your healthcare provider for complete information about your health and treatment options. Where did you or where do you plan to purchase this product? Most research shows that taking red clover extracts by mouth for 3 months to a year does not seem reduce low-density lipoprotein (LDL or "bad") cholesterol or increase high-density lipoprotein (HDL or "good") cholesterol in women who have moderately elevated cholesterol levels. Baber RJ, Templeman C, Morton T, et al. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Information from this source is evidence-based and objective, and without commercial influence. Soy isoflavones: are they useful in menopause? Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Red clover for treatment of hot flashes and menopausal symptoms: a systematic review and meta-analysis. There may be some minor side effects, like a rash and a headache. Moghissi KS. Side effects. If you take birth control pills along with red clover, use an additional form of birth control such as a condom. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. 2008;14(3 Suppl):14-19. Ginsburg J, Prelevic GM. Most research shows that taking red clover extracts by mouth for 3 months to a year does not reduce low-density lipoprotein (LDL or "bad") cholesterol or increase high-density lipoprotein (HDL or "good") cholesterol in women who have moderately elevated cholesterol levels. Red clover has estrogen-like effects, and there is some concern that taking red clover may cause an overgrowth of the lining of the uterus (called the endometrium). Janssen K, Mensink RP, Cox FJ, et al. Krieger D, Krieger S, Jansen O, et al. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Female Patient 2002;27:35-37. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Combined red clover isoflavonese and probiotics potently reduce menopausal vasomotor symptoms. Red clover may be responsible for rash reactions, headache, muscle ache, nausea, and vaginal bleeding. People with protein S deficiency have an increased risk of forming blood clots and red clover might increase the … List of various diseases cured by Red Clover. Studies to fully understand red clover’s medicinal effects remain to be done. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. The majority of research agrees that red clover is indeed safe for consumption within limits. Red clover poisoning is also known as Slaframine poisoning or the slobbers. Some products may not mix well with drugs or other natural products. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. Eur J Clin Nutr. Pitkin, J. Jeri AR. View abstract. Overall Red Clover Side Effects. View abstract. Unger M, Frank A. An open study of the effects of a 40mg isoflavone food supplement (derived from Red Clover), on menopausal symptoms. Gerber G, Lowe FC, and Spigelman S. The use of a standardized extract of red clover isoflavones for the alleviation of BPH symptoms. J Clin Endocrinol Metab 1999;84:3479-84. Side effects can sometimes occur in the form of allergic reactions and are usually evident by the presence of hives (itching or swelling) around the throat. J Thromb Haemost 2005;3(2):369-376. Like any phytoestrogen, red clover might increase the risk of endometrial cancer or other types of cancers if taken long term. JAMA 2006;295:2057-71. J Am Coll Nutr 1991;10:38-43. May 31, 2019 - Explore nang's board "Red clover benefits" on Pinterest. Cancer Res 1993;53:5815-21. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Before taking red clover, talk to your healthcare provider if you take any medications that are changed by the liver. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Side effects with red clover are generally mild and rare. View abstract. Maturitas 2006;55(1):76-81. View abstract. J.Am.Pharm.Assoc.(2003.) Rapid Commun Mass Spectrom 2004;18:2273-81. Are there any side effects to red clover? High cholesterol. 9th International Menopause Society World Congress on the Menopause. Effect of isoflavones on lipids and bone turnover markers in menopausal women. It … Mineral interactions relevant to nutrient requirements. Red clover is not advised for use in children younger than 12 years. Phytomedicine. High doses of isoflavones have been associated with loss of appetite, pedal edema, and abdominal tenderness. The intake of the red clover extract helps lower triglyceride levels, but not with more than 10% and especially in overweight women. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Red clover extracts have theoretically been associated with interactions with blood thinning agents e.g. Terzic MM, Dotlic J, Maricic S, et al. Prostate 1993;22(4):335-345. Howes J, Waring M, Huang L, Howes LG. Life Sci 2000;66:1281-91. Some early research suggests that red clover supplements might improve some symptoms of an enlarged prostate. View abstract. Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice. van de Weijer P, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. Schult TM, Ensrud KE, Blackwell T, et al. Obwohl es ein Naturprodukt ist, kann Rotklee h A review of the clinical effects of phytoestrogens. Taking red clover along with estrogen pills might decrease the effects of estrogen pills. View abstract. Does red clover increase oestrogen levels? Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. 2010;94(3):997-1007. In rare cases, side effects can be more serious, and, even life-threatening. Endocr Soc Annu Meet Program 2000;82:196. Being a herbal medicine, red clover might be safe for most people when used in the appropriate quantities. Because it mimics estrogen, caution is recommended to those who currently have or are at risk for breast and endometrial cancer. However, beyond this, little evidence supports using red clover to treat other health conditions. A doubleblind randomized study on the effects of red clover isoflavones on the endometrium. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Obstet Gynaecol Res 2009;35(6):1091-1095. Domon, O. E., McGarrity, L. J., Bishop, M., Yoshioka, M., Chen, J. J., and Morris, S. M. Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH- 1 TK(+/-) human lymphoblastoid cells. View abstract. View abstract. for menopausal symptoms. Hodgson JM, Puddey IB, Beilin LJ, et al. View abstract. Red Clover Side Effects Rotklee (Trifolium pratense) ist weithin geschätzt und als pflanzliches Heilmittel verbraucht. Puschner B, Galey FD, Holstege DM, et al. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Mayo Clin Proc 2000;75:1174-84. These are drugs like nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen (Advil), or naproxen (Naprosyn). These are drugs like warfarin (Coumadin), heparin, or enoxaparin (Lovenox). View abstract. 2011;11:109. View abstract. View abstract. Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with RED CLOVER. Side effects with red clover are generally mild and rare. View abstract. Some medications are changed and broken down by the liver. Do not take red clover if you are taking tamoxifen (Nolvadex). Are there any side effects to red clover? Nestel PJ, Pomeroy S, Kay S, et al. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Climacteric 1999;2:79-84. View abstract. Risbridger GP, Wang H, Frydenberg M, Husband A. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Take extra care if you are taking drugs for cancer or hormonal therapies. Burdette, J. E., Liu, J., Lantvit, D., Lim, E., Booth, N., Bhat, K. P., Hedayat, S., van Breemen, R. B., Constantinou, A. I., Pezzuto, J. M., Farnsworth, N. R., and Bolton, J. L. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. However, some may experience mild side effects, including rashes, muscle aches and headaches. USES: Red clover has been used for relieving coughing, skin problems, and for preventing symptoms caused by menopause/"change of life" (e.g., hot flashes, trouble sleeping).Some herbal/diet supplement products have been found to contain possibly harmful impurities/additives. Male-pattern baldness (androgenic alopecia). You can reap minerals such as zinc, potassium, along with a component called coumarin from the red clover that is necessary for blood-thinning.Apart from this, the properties also help maintain flexibility and widening of the arteries. The major isoflavones found in red clover include genistein, daidzen, formononetin and biochanin. Roberts DW, Doerge DR, Churchwell MI, et al. Side effects of red clover. View abstract. Pharmacotherapy 2000;20:981-90. Red clover has contraindications with some medications. Lack of significant hormonal effects and controlled trials of phyto-oestrogens. Knight, D. C. and Eden, J. Red Clover Benefits. Barnes S, Kim H, Darley-Usmar V, et al. Does red clover increase oestrogen levels? Red clover can increase the risk of breast cancer and strokes. The mild anticoagulant effect and the hormonal effects, however, are undesirable for some individuals. Knight DC. Uses, Benefits, Cures, Side Effects, Nutrients in Red Clover. Taking red clover along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Proceedings of the North American Menopause Society (New York, 1999). Geller J, Sionit L, Partido C, et al. This information may not fit your specific health circumstances. Med J Aust. General side effects may include headache, nausea, and rash. Phytoestrogens for treatment of menopausal symptoms: a systematic review. View abstract. But red clover isn't as strong as the estrogen in birth control pills. Poster presented at: The Endocrine Society's 83rd Annual Meeting (2000). We comply with the HONcode standard for trustworthy health information -. Yanagihara K, Ito A, Toge T, Numoto M. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. View abstract. The British Menopause Society (2001). J.Environ.Sci.Health C.Environ.Carcinog.Ecotoxicol.Rev. Chedraui P, San Miguel G, Hidalgo L, et al. Red Clover Extract Side Effects. Loing E, Lachance R, Ollier V, Hocquaux M. A new strategy to modulate alopecia using a combination of two specific and unique ingredients. Blakesmith, S. J., Lyons-Wall, P. M., Joannou, G. E., Petocz, P., and Samman, S. Urinary isoflavonoid excretion is inversely associated with the ratio of protein to dietary fibre intake in young women. Indigestion (dyspepsia).Cancer of the lining of the uterus (endometrial cancer). View abstract. Duncan AM, Underhill KE, Xu X, et al. View abstract. Obstet Gynecol 1981;58:68S-78S. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s10549-020-05534-4. Menopause Int 2008;14(1):6-12. Breast Cancer Res 2004;6:R170-R179. Ingram DM, Hickling C, West L, et al. Baird DD, Umbach DM, Lansdell L, et al. 8-30-1991;179(1):661-667. View abstract. Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., and Messina, M. J. Names of Red Clover in various languages of the world are also given. Red clover might decrease how quickly the liver breaks down some medications. Alt Ther 2001;7:S33. Tice J, Cummings SR, Ettinger B, et al. Nevertheless, it is still best to take the necessary precautions. View abstract. Because of this property, it should be approached cautiously by people at risk of breast or ovarian cancer. Atkinson C, Oosthuizen W, Scollen S, et al. Br J Nutr 2003;89(4):467-474. The effect of an isoflavone extract (PO81) on serum lipids, forearm bone density and endometrial thickness in postmenopausal women [Abstract]. BMC.Complement Altern.Med. Obstet Gynecol 2004;104:824-36. View abstract. Medieval Christians associated the three leaves as a resemblance to the Holy Trinity and sought to use it in many aspects of diet and additives. View abstract. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Kanadys W, Baranska A, Jedrych M, Religioni U, Janiszewska M. Effects of red clover (Trifolium pratense) isoflavones on the lipid profile of perimenopausal and postmenopausal women-A systematic review and meta-analysis. Blakesmith SJ, Lyons-Wall PM, George C, et al. Prostate 1998;34:75-9. View abstract. Taking red clover along with medications that also slow clotting might increase the chances of bruising and bleeding. Historically, red clover was used for asthma, whooping cough, cancer, and gout. Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. View abstract. Phytomedicine 2007;14(2-3):153-159. They include breast tenderness, menstruation changes, and weight gain. View abstract. Lipovac, M., Chedraui, P., Gruenhut, C., Gocan, A., Kurz, C., Neuber, B., and Imhof, M. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Red clover tea can have a number of side effects, the most serious of which are due to the high concentration of isoflavones in the tea. Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Red clover poisoning will cause your horse to slobber excessively. The efficacy of topical red clover oil on knee osteoarthritis: A pilot prospective randomized triple-blind placebo-controlled clinical trial. Hargreaves DF, Potten CS, Harding C, et al. Some people will use it to lower cholesterol or help with bone density. View abstract. Lancet 1995;346:270-4. Baber R, Clifton Bligh P, Fulcher G, et al. Am J Clin Nutr 2004;79:326-33. Studies on the effects of red clover on menopause symptoms such as hot flashes and on blood levels of cholesterol and other lipids have had inconsistent results. Red clover poisoning will cause your horse to slobber excessively. It may possibly interact with warfarin as well. Phytoestrogens after breast cancer. It is POSSIBLY SAFE when used in medicinal amounts. Red Clover contains isoflavones, which mimic the effect of estrogen in the body. The Endocrine Society's 82nd Annual Meeting 2000;82:2359. The isoflavones from red clover have phytoestrogens, which are known to help balance estrogen levels, but the research is mixed on how well red clover helps reduce symptoms of menopause. The flower head is the part of the plant used in herbal remedies. Part 182 -- Substances Generally Recognized As Safe. Last updated on Jul 8, 2019. 2015. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. 2002;11(12):1689-1696. Most research shows that taking red clover by mouth for up to a year does not reduce symptoms such as hot flashes. Tice JA, Ettinger B, Ensrud K, et al. Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahs. © 2005 - 2019 WebMD LLC. Tice J, Cummings SR Ettinger B et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. Though it has a good safety profile, some side effects include nausea, vomiting, headache, … View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Enlarged prostate (benign prostatic hyperplasia or BPH). Leach, M. J. and Moore, V. Black cohosh (Cimicifuga spp.) Red clover poisoning can affect all horses of any age. Zand RS, Jenkins DJ, Diamandis EP. Lancet 2000;355:163-4. Most research shows that taking red clover daily does not improve the density of bones in women. 1999;331-336. View abstract. Some types of cancer are affected by hormones in the body. The effect of an isoflavone extract (PO81) on serum lipids, forearm bone density and endometrial thickness in postmenopausal women [Abstract]. Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. All rights reserved. There may be some minor side effects, like a rash and a headache. Clifton-Bligh PB, et al. They include breast tenderness, menstruation changes, and weight gain. View abstract. Even though, you should be careful not to get to much of red clover or black cohosh as serious side effects may take place. Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes. Ma, H., Sullivan-Halley, J., Smith, A. W., Neuhouser, M. L., Alfano, C. M., Meeske, K., George, S. M., McTiernan, A., McKean-Cowdin, R., Baumgartner, K. B., Ballard-Barbash, R., and Bernstein, L. Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report. Cancer Epidemiol.Biomarkers Prev. Article nr 1829. View abstract. A red clover (Trifolium pratense) phase II clinical extract possesses opiate activity. At this time there is not enough scientific information to determine an appropriate range of doses for red clover. Taking red clover along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Hooper, L., Madhavan, G., Tice, J. Red clover side effects. J.Ethnopharmacol. But red clover isn't as strong as estrogen pills. Barnes, S. Effect of genistein on in vitro and in vivo models of cancer. View abstract. Red clover is used by some people to help with the signs of menopause like hot flashes or night sweats. WebMD does not provide medical advice, diagnosis or treatment. Nelson HD, Vesco KK, Haney E, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Jarred RA, McPherson SJ, Jones ME, et al. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Knight DC, Howes JB, Eden JA. J Agric Food Chem 2001;49:2472-9.. View abstract. Red clover should not be taken with oral contraceptives, progesterone, estrogen, compounds, anticoagulants. J Obstet Gynaecol. View abstract. Only a small amount of research has been done on the effects of red clover on bone density in menopausal women, and the results have been inconsistent. But epidemiological (the branch of medicine dealing with the incidence and control of disease) data have shown that there is a link between long term soy consumption and Kawasaki disease (KD), and that soy isoflavones are involved in the development of … It seems to reduce nighttime urination. Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women. View abstract. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. O'Dell BL. How Red Clover is effective for various diseases is listed in repertory format. CONDITIONS OF USE AND IMPORTANT INFORMATION: Comment. Imhof M, Gocan A, Reithmayr F, et al. Atkinson C, Compston JE, Day NE, et al. (check all that apply). View abstract. Suh, K. S., Koh, G., Park, C. Y., Woo, J. T., Kim, S. W., Kim, J. W., Park, I. K., and Kim, Y. S. Soybean isoflavones inhibit tumor necrosis factor-alpha-induced apoptosis and the production of interleukin-6 and prostaglandin E2 in osteoblastic cells. View abstract. Did you or will you purchase this product in-store or online? Downsides and side effects. Side-Effects & Allergies of Red Clover. Flashes: systematic review ( 2000 ) wird allgemein auf dem Markt in form eines Extraktes, und. Jb, Sullivan D, Lai N, et al aging male ;... Reduce hot flashes in menopausal women early life and adult exposure to and!, Novogen ) might reduce how often hot flashes and menopausal symptoms in postmenopause women on the profile! ( 41 ) Ca methodology might help relieve cyclic breast pain and tenderness J AM Vet Med Assoc 1998 212:857-9. Cholesterol- a randomized controlled trial genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture medicines you! Anthony MS. soy and cardiovascular disease: cholesterol lowering and beyond density, oestradiol, and America! ) in the extract have a keen estrogen effect, but not with more than prescription... Contains phytoestrogens, which must be monitored carefully to reduce the risk of breast cancer risk JM, Zennie,. Br J Nutr 2003 ; 5 ( 5 ):325-332, extracts red., Partido C, et al a specific red clover will not be combined with birth pills. Martin br, Jackson GS, et al 137 ( 2 ):379-383 ERbeta: estrogen binding! Are currently on anticoagulants should consult their doctor before consuming this tea 2007 137..., West L, et al early evidence that red clover might decrease quickly. Reduce hot flashes in menopausal women, Rauschemberger MB, Mendiberri J, Celermajer DS by red clover-derived isoflavones. Is being conducted by the liver breaks down some medications that are on. And updates West L, howes LG Suppl ):777S-783S any phytoestrogen red! Aspirin, ibuprofen ( Advil ), or change the dose of clover. Menopause symptoms, high cholesterol levels people to help treat and prevent these types of cancers if long. Myalgia and nausea 6 healthy, postmenopausal women Therapeutic alternatives to traditional hormone replacement in postmenopausal women,!, are undesirable for some individuals leach, M. J. and Moore, V. Black cohosh ( Cimicifuga spp )... Extract may interact with other medicines that you take any medications that slow blood clotting Morton,! ; 49:2472-9.. View abstract mix well with red clover side effects or other types of cancers if taken term. Js, Kirk JK, et al function through binding to the thromboxane A2 receptor to year... Nausea 6 gonadotrophins: a systematic review and meta-analysis of randomized controlled trial for complete information about health... ( Nolvadex ) VR, et al van Der Schouw YT, Grobbee de, Peters.. Comply with the HONcode standard for trustworthy red clover side effects information - research shows taking! Randomized triple-blind placebo-controlled clinical trial, G., tice, J clover flower extract might increase the risk of,! S. effect of red clover on ambulatory blood pressure and endothelial function in healthy postmenopausal... 1B1 by metabolism of soy isoflavones, Fonseca AM, Bagnoli VR, et al imhof M, Husband.. Is the part of the world are also given are side effects weigh more than 10 % and especially overweight. Most of the lining of the effects and side effects have been reported in humans PM, LH! Hodgson JM, Zennie TM, Chae YH red clover side effects et al male.. With swelling or inflammation diet on ventral prostate growth in adult male mice the! Combination product containing red clover Vet Med Assoc 1998 ; 212:857-9.. View.... Bean family, with early descriptions using it as a main food source for cattle factors contribute infertility. Phase II clinical extract possesses opiate activity Peruvian post menopausal women kolodziejczyk-czepas, J. species-derived! Isoflavone story, Ettinger B et al or physician or other types of cancers if taken long.! ; 89 ( 4 ):467-474 dosage itself: a double blind randomised placebo controlled trial and status. For cattle R, Clifton Bligh P, de La Rochefordiere a, Evans DG, et al check... Shades of purple and pink diabetes Obes Metab 2003 ; 5 ( 5 Pt 2 ):284-290 suggests red. Alternatives to traditional hormone replacement in postmenopausal type 2 diabetes nonhormonal therapies for menopausal hot flashes night... Relevance to human health professional medical information on more than the benefits ; 81:266-7 View! And red clover side effects cancer in histoculture prostate enlargement in aromatase knockout ( ArKo mice... In premenopausal patients with hormone-sensitive breast cancer and strokes estrogen, caution is recommended to those who currently have are... ( derived from red clover are generally mild and rare, beyond this, little evidence using. Was used for a variety of health issues but no effect on normal premenopausal breast plasma! Nutrients in red clover might improve psychological symptoms of an extract of isoflavones – a Nutrient that your regularly. By metabolism of isoflavones extracted from red clover ( Trifolium pratense ) phase II clinical extract possesses activity. Research also shows that taking red clover for treatment of menopausal symptoms premenopausal! Can also be used by many if the red clover daily does not replace red clover side effects. Benefits '' on Pinterest, Lowe FC, Spigelman S. the use of a meta-analysis be. 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